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Article

Current insights into LMNA cardiomyopathies: Existing models and missing LINCs.

Nucleus (Austin, Tex.) - 2 Jan 2017

Brayson Daniel, Shanahan Catherine M

Abstract excerpt

The nuclear lamina is a critical structural domain for the maintenance of genomic stability and whole-cell mechanics. Mutations in the LMNA gene, which encodes nuclear A-type lamins lead to the disruption of these key cellular functions, resulting in a number of devastating diseases known as laminopathies. Cardiomyopathy is a common laminopathy and is highly penetrant with poor prognosis. To date, cell mechanical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28125396
DOI: 10.1080/19491034.2016.1260798
PMCID: PMC5287098

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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