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Article

Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.

Human molecular genetics - 1 Nov 2004

Broers Jos L V, Peeters Emiel A G, Kuijpers Helma J H, Endert Jorike, Bouten Carlijn V C, Oomens Cees W J, Baaijens Frank P T, Ramaekers Frans C S

Abstract excerpt

Laminopathies comprise a group of inherited diseases with variable clinical phenotypes, caused by mutations in the lamin A/C gene (LMNA). A prominent feature in several of these diseases is muscle wasting, as seen in Emery-Dreifuss muscle dystrophy, dilated cardiomyopathy and limb-girdle muscular...

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Source

Identifiers

PMID: 15367494
DOI: 10.1093/hmg/ddh295

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15367494-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Decreased mechanical stiffness in LMNA-/- cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies.PMID 15367494Read ↗

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Nuclear damage in <i>LMNA</i> mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelopeSemantic proximity Read ↗

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Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells.Semantic proximity Read ↗

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