Article

Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin

2024-05-17

Abstract excerpt

<title>Abstract</title> <p>Toxic protein aggregates are associated with various neurodegenerative diseases, including Huntington’s disease (HD). Since no current treatment delays the progression of HD, we developed a mechanistic approach to preventing mutant huntingtin (mHttex1) aggregation. Here, we engineered the ATP-independent cytosolic chaperone PEX19, which targets peroxisomal membrane proteins to peroxisom...

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Literature Corpus work: 384b993e-0060-5cd0-95d1-caa2206758d1
DOI: 10.21203/rs.3.rs-4292547/v1

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