Article

Plectin-mediated cytoskeletal crosstalk as a target for inhibition of hepatocellular carcinoma growth and metastasis

2024-08-06

Abstract excerpt

The most common primary malignancy of the liver, hepatocellular carcinoma (HCC), is a heterogeneous tumor entity with high metastatic potential and complex pathophysiology. Increasing evidence suggests that tissue mechanics plays a critical role in tumor onset and progression. Here we show that plectin, a major cytoskeletal crosslinker protein, plays a crucial role in mechanical homeostasis and mechanosensitive on...

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Identifiers and source

Literature Corpus work: 383b9dac-32ae-5d22-bcc6-490948713412
DOI: 10.1101/2024.08.02.606331

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