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Article

TGF-β-induced PLEK2 promotes metastasis and chemoresistance in oesophageal squamous cell carcinoma by regulating LCN2.

Cell death & disease - 2 Oct 2021

Wang Feng, Zhang Chaoqi, Cheng Hong, Liu Chengming, Lu Zhiliang, Zheng Sufei, Wang Sihui, Sun Nan, He Jie

Abstract excerpt

Oesophageal squamous cell carcinoma (ESCC) has a relatively unfavourable prognosis due to metastasis and chemoresistance. Our previous research established a comprehensive ESCC database (GSE53625). After analysing data from TCGA database and GSE53625, we found that PLEK2 predicted poor prognosis in ESCC. Moreover, PLEK2 expression was also related to the overall survival of ESCC patients undergoing chemotherapy....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34601488
DOI: 10.1038/s41419-021-04155-z
PMCID: PMC8487427

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