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Article

Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration.

Gastroenterology - 1 Apr 2018

Zhang Shuyuan, Nguyen Liem H, Zhou Kejin, Tu Ho-Chou, Sehgal Alfica, Nassour Ibrahim, Li Lin, Gopal Purva, Goodman Joshua, Singal Amit G, Yopp Adam, Zhang Yu, Siegwart Daniel J, Zhu Hao

Abstract excerpt

BACKGROUND & AIMS: Cytokinesis can fail during normal postnatal liver development, leading to polyploid hepatocytes. We investigated whether inhibiting cytokinesis in the liver slows tumor growth without compromising the health of normal hepatocytes. We inhibited cytokinesis in cancer cells by knocking down ANLN, a cytoskeletal scaffolding protein that regulates cytokinesis and might promote tumorigenesis, in...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29274368
DOI: 10.1053/j.gastro.2017.12.013
PMCID: PMC5880685

Genes

ANLN
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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