Article

High-Throughput Developability Assays Enable Library-Scale Identification of Producible Protein Scaffold Variants

2020-12-15

Abstract excerpt

Proteins require high developability - quantified by expression, solubility, and stability - for robust utility as therapeutics, diagnostics, and in other biotechnological applications. Measuring traditional developability metrics is low-throughput in nature, often slowing the developmental pipeline. We evaluated the ability of three high-throughput developability assays to predict the bacterial recombinant expres...

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Literature Corpus work: 38143074-1ae9-521a-9af3-b37457c2ed1e
DOI: 10.1101/2020.12.14.422755

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