Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A 45-Amino-Acid Scaffold Mined from the PDB for High-Affinity Ligand Engineering.

Chemistry & biology - 23 Jul 2015

Kruziki Max A, Bhatnagar Sumit, Woldring Daniel R, Duong Vandon T, Hackel Benjamin J

Abstract excerpt

Small protein ligands can provide superior physiological distribution compared with antibodies, and improved stability, production, and specific conjugation. Systematic evaluation of the PDB identified a scaffold to push the limits of small size and robust evolution of stable, high-affinity ligands: 45-residue T7 phage gene 2 protein (Gp2) contains an α helix opposite a β sheet with two adjacent loops amenable to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Databases, Protein
Share to ErbB Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Models, Molecular

Share to Protein Engineering

Share to Protein Structure, Tertiary

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 26165154
DOI: 10.1016/j.chembiol.2015.06.012
PMCID: PMC4536934

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A 45-Amino-Acid Scaffold Mined from the PDB for High-Affinity Ligand Engineering.PMID 26165154Read ↗

Phage display technology and its impact in the discovery of novel protein-based drugsSemantic proximity Read ↗

Construction of a large phage-displayed human antibody domain library with a scaffold based on a newly identified highly soluble, stable heavy chain variable domain.Semantic proximity Read ↗

Constrained Combinatorial Libraries of Gp2 Proteins Enhance Discovery of PD-L1 Binders.Semantic proximity Read ↗

Advances in phage display technology for drug discoverySemantic proximity Read ↗

High-throughput protein binder discovery by rapid in vivo selectionSemantic proximity Read ↗

Robust de novo design of protein binding proteins from target structural information aloneSemantic proximity Read ↗

Ribosome Display: A Potent Display Technology used for Selecting and Evolving Specific Binders with Desired PropertiesSemantic proximity Read ↗

Identification of optimal protein binders through the use of large genetically encoded display librariesSemantic proximity Read ↗

Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold LibrarySemantic proximity Read ↗

Picomolar affinity fibronectin domains engineered utilizing loop length diversity, recursive mutagenesis, and loop shuffling.Semantic proximity Read ↗

Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments.Semantic proximity Read ↗

A general method for greatly improving the affinity of antibodies by using combinatorial libraries.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.