Article
Open innovation for phenotypic drug discovery: The PD2 assay panel.
Journal of biomolecular screening - 1 Jul 2011
Lee Jonathan A, Chu Shaoyou, Willard Francis S, Cox Karen L, Sells Galvin Rachelle J, Peery Robert B, Oliver Sarah E, Oler Jennifer, Meredith Tamika D, Heidler Steven A, Gough Wendy H, Husain Saba, Palkowitz Alan D, Moxham Christopher M
Abstract excerpt
Phenotypic lead generation strategies seek to identify compounds that modulate complex, physiologically relevant systems, an approach that is complementary to traditional, target-directed strategies. Unlike gene-specific assays, phenotypic assays interrogate multiple molecular targets and signaling pathways in a target "agnostic" fashion, which may reveal novel functions for well-studied proteins and discover new...
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