Article

SAP expressing T peripheral helper cells identify systemic lupus erythematosus patients with lupus nephritis

2023-11-17

Abstract excerpt

<h4>Introduction</h4> T follicular (TFH) and peripheral helper (TPH) cells have been increasingly recognized as a pathogenic subset of CD4 T cells in systemic lupus erythematosus (SLE). The SLAM Associated Protein (SAP) regulates TFH and TPH function by binding to the co -stimulatory signaling lymphocyte activation molecule family (SLAMF) receptors that mediate T cell – B cell interactions. SAP and SLAMF are crit...

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Literature Corpus work: 37ed70ad-9869-52e9-b395-968dde3a02f8
DOI: 10.1101/2023.11.16.566902

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