Article

Clonal relationships between Tph and Tfh cells in patients with SLE and in murine lupus

2025-01-29

Abstract excerpt

Pathologic T cell-B cell interactions drive disease in systemic lupus erythematosus (SLE). The T cells that activate B cell responses include T peripheral helper (Tph) and T follicular helper (Tfh) cells, yet the developmental and clonal relationships between these B cell-helper T cell populations are unclear. Here we use T cell receptor (TCR) profiling to demonstrate substantial clonal overlap between Tph and Tfh...

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Literature Corpus work: 1b449a8d-df23-53c1-a707-b8f1ce0d8eb0
DOI: 10.1101/2025.01.27.635189

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