Article

Hipk is required for JAK/STAT activity and promotes hemocyte-derived tumorigenesis

2016-06-10

Abstract excerpt

Dysregulation of key signaling molecules and pathways are causative of many Human diseases and cancers. A point mutation in the Drosophila Janus kinase (called hop ) causes constitutive activation of the JAK/STAT pathway and results in blood cell tumours. We provide robust genetic evidence that Hipk is required for endogenous JAK/STAT activity. Overexpression of Hipk can phenocopy the effects of overactive JAK/ST...

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Literature Corpus work: 37e2f727-625d-5d17-974d-625faea20782
DOI: 10.1101/058156

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