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Article

Hipk is required for JAK/STAT activity during development and tumorigenesis

31 Dec 2019

Abstract excerpt

Drosophila has been instrumental as a model system in studying signal transduction and revealing molecular functions in development and human diseases. A point mutation in the Drosophila Janus kinase JAK (called hop) causes constitutive activation of the JAK/STAT pathway. We provide robust genetic evidence that the Homeodomain interacting protein kinase (Hipk) is required for endogenous JAK/STAT activity....

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PMID: 31891940
DOI: 10.1371/journal.pone.0226856

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