Article
An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects.
The EMBO journal - 3 Apr 1995
Luo H, Hanratty W P, Dearolf C R
Abstract excerpt
Proteins of the Jak family of non-receptor kinases play important roles in mammalian hematopoietic signal transduction. They mediate the cellular response to a wide range of cytokines and growth factors. A dominant mutation in a Drosophila Jak kinase, hopscotchTumorous-lethal (hopTum-l), causes hematopoietic defects. Here we conduct a molecular analysis of hopTum-l. We demonstrate that the hopTum-l hematopoietic...
Topics
- Animals
- Animals, Genetically Modified
- Base Sequence
- Crosses, Genetic
- DNA Primers
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Genes, Lethal
- Genotype
- Hematopoiesis