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Article

Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis

14 Dec 2018

Abstract excerpt

Over the past three-decades, Janus kinase (Jak) and signal transducer and activator of transcription (STAT) signaling has emerged as a paradigm to understand the involvement of signal transduction in development and disease pathology. At the molecular level, cytokines and interleukins steer Jak/STAT signaling to transcriptional regulation of target genes, which are involved in cell differentiation, migration, and...

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PMID: 30558204
DOI: 10.3390/ijms19124056

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