Article
Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways.
Molecular and cellular biology - 1 Mar 1997
Luo H, Rose P, Barber D, Hanratty W P, Lee S, Roberts T M, D'Andrea A D, Dearolf C R
Abstract excerpt
The Jak (Janus) family of nonreceptor tyrosine kinases plays a critical role in cytokine signal transduction pathways. In Drosophila melanogaster, the dominant hop(Tum-l) mutation in the Hop Jak kinase causes leukemia-like and other developmental defects. Previous studies have suggested that the...
Topics
- Amino Acid Sequence
- Animals
- COS Cells
- DNA
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Glutamic Acid
- Janus Kinase 2
- Janus Kinases
- Leukemia, Experimental
- Male
- Melanins
- Mice
- Milk Proteins
- Molecular Sequence Data
- Neoplasms, Experimental