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Article

HIPK2 directs cell type–specific regulation of STAT3 transcriptional activity in Th17 cell differentiation

28 Mar 2022

Abstract excerpt

Significance STAT3 (signal transducer and activator of transcription 3) is a master transcription factor that organizes cellular responses to cytokines and growth factors and is implicated in inflammatory disorders. STAT3 is a well-recognized therapeutic target for human cancer and inflammatory disorders, but how its function is regulated in a cell type–specific manner has been a major outstanding question. We...

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PMID: 35344430
DOI: 10.1073/pnas.2117112119

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