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Functional characterization of human Homeodomain-interacting protein kinases (HIPKs) in Drosophila melanogaster reveal both conserved functions and differential induction of HOX gene expression

2020-11-03

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Homeodomain-interacting protein kinases (Hipks) are a family of conserved proteins that are necessary for development in both invertebrate and vertebrate organisms. Vertebrates have four paralogues, Hipks 1-4. Mice lacking Hipk1 or Hipk2 are viable, however loss of both is lethal during early embryonic development, with embryos exhibiting homeotic skeletal transformations and incorrect HOX gene expression. While...

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Literature Corpus work: 32ca68d2-57c0-5031-bdd8-ce71f1407e7a
DOI: 10.1101/2020.11.03.366393

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