Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Focused Ultrasound-Mediated Disruption of the Blood–Brain Barrier for AAV9 Delivery in a Mouse Model of Huntington’s Disease

24 May 2024

Abstract excerpt

gene. There are no cures for HD, but the genetic basis of this disorder makes gene therapy a viable approach. Adeno-associated virus (AAV)-miRNA-based therapies have been demonstrated to be effective in lowering HTT mRNA; however, the blood-brain barrier (BBB) poses a significant challenge for gene delivery to the brain. Delivery strategies include direct injections into the central nervous system, which are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Viral Infections and Immunology Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38931834
DOI: 10.3390/pharmaceutics16060710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Focused Ultrasound-Mediated Disruption of the Blood–Brain Barrier for AAV9 Delivery in a Mouse Model of Huntington’s DiseasePMID 38931834Read ↗

Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression.Semantic proximity Read ↗

Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson’s disease: from rodent models to non-human primatesSemantic proximity Read ↗

Ultrasound-Mediated Gene Therapy in Alzheimer’s Disease Validated through In Vivo PET ImagingSemantic proximity Read ↗

A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodiesSemantic proximity Read ↗

Engineering Viral Vectors for Acoustically Targeted Gene DeliverySemantic proximity Read ↗

Engineering viral vectors for acoustically targeted gene deliverySemantic proximity Read ↗

PET imaging of focused-ultrasound enhanced delivery of AAVs into the murine brainSemantic proximity Read ↗

Self-inactivating AAV-CRISPR at different ages enables sustained amelioration of Huntington’s disease deficits in BAC226Q miceSemantic proximity Read ↗

The advent of AAV9 expands applications for brain and spinal cord gene deliverySemantic proximity Read ↗

AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington's disease.Semantic proximity Read ↗

Focused Ultrasound Blood-Tumor Barrier Opening Rapidly Augments Intratumor CD4 and CD8 T Cell Representation in a Genetically Engineered Mouse Model of GliomaSemantic proximity Read ↗

Exon 1-targeting miRNA reduces the pathogenic exon 1 HTT protein in Huntington's disease modelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.