Article

Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson’s disease: from rodent models to non-human primates

2025-03-03

Abstract excerpt

<h4>ABSTRACT</h4> Gene therapy for neurodegenerative diseases faces significant challenges due to the blood-brain barrier (BBB), which limits drug delivery to the central nervous system (CNS). While clinical trials for Parkinson’s disease (PD) have progressed, administration of vectors expressing enzymatic or neurotrophic factor transgenes have required extensive optimization of the delivery method to achieve pot...

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Literature Corpus work: 0a8e8628-c993-58d4-8576-14e24e8b5379
DOI: 10.1101/2025.03.02.639893

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Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson’s disease: from rodent models to non-human primatesDOI 10.1101/2025.03.02.639893Read

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