Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson's Disease.

Scientific reports - 20 Jan 2016

Fan Ching-Hsiang, Ting Chien-Yu, Lin Chung-Yin, Chan Hong-Lin, Chang Yuan-Chih, Chen You-Yin, Liu Hao-Li, Yeh Chih-Kuang

Abstract excerpt

Glial cell line-derived neurotrophic factor (GDNF) supports the growth and survival of dopaminergic neurons. CNS gene delivery currently relies on invasive intracerebral injection to transit the blood-brain barrier. Non-viral gene delivery via systematic transvascular route is an attractive alternative because it is non-invasive, but a high-yield and targeted gene-expressed method is still lacking. In this study,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood-Brain Barrier
Share to Gene Transfer Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Therapy

Share to Glial Cell Line-Derived Neurotrophic Factor

Share to Motor Activity

Share to Parkinson Disease

Share to Permeability

Share to Plasmids

Source

Open in PubMed Open full text

Identifiers

PMID: 26786201
DOI: 10.1038/srep19579
PMCID: PMC4726227

Genes

GDNF
FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Noninvasive, Targeted, and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson's Disease.PMID 26786201Read ↗

Portable transcranial therapeutic ultrasound enhances targeted gene delivery for Parkinson’s disease: from rodent models to non-human primatesSemantic proximity Read ↗

Ultrasonic particles: An approach for targeted gene deliverySemantic proximity Read ↗

ULTRASOUND-ASSISTED MAGNETIC NANOPARTICLE-BASED GENE DELIVERYSemantic proximity Read ↗

Putaminal Recombinant Glucocerebrosidase Delivery with Magnetic Resonance-Guided Focused Ultrasound in Parkinson's Disease: A Phase I Study.Semantic proximity Read ↗

Focused ultrasound increases gene delivery to deep brain structure following the administration of a recombinant adeno-associated virus in the cerebrospinal fluidSemantic proximity Read ↗

Enhancing the delivery of SOD1 antisense oligonucleotides to the murine brain using lipid nanoparticles and image-guided focused ultrasoundSemantic proximity Read ↗

Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression.Semantic proximity Read ↗

First-in-human prospective trial of sonobiopsy in glioblastoma patients using neuronavigation-guided focused ultrasoundSemantic proximity Read ↗

Ultrasound-Mediated Gene Therapy in Alzheimer’s Disease Validated through In Vivo PET ImagingSemantic proximity Read ↗

A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodiesSemantic proximity Read ↗

Gene therapy for Parkinson’s disease: contemporary practice and emerging conceptsSemantic proximity Read ↗

Engineering Viral Vectors for Acoustically Targeted Gene DeliverySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.