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Dysfunctional mitochondria in ageing T cells: a perspective on mitochondrial quality control mechanisms

29 Aug 2025

Abstract excerpt

Dysfunctional mitochondria are a hallmark of T cell ageing and contribute to organismal ageing. This arises from the accumulation of reactive oxygen species (ROS), impaired mitochondrial dynamics, and inefficient removal of dysfunctional mitochondria. Both cell-intrinsic and cell-extrinsic mechanisms for removing mitochondria and their byproducts have been identified in T cells. In this review, we explore how T...

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PMID: 40883510
DOI: 10.1038/s44319-025-00536-z

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