Article
The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Feb 2024
Dalmasso Maria Carolina, de Rojas Itziar, Olivar Natividad, Muchnik Carolina, Angel Bárbara, Gloger Sergio, Sanchez Abalos Mariana Soledad, Chacón María Victoria, Aránguiz Rafael, Orellana Paulina, Cuesta Carolina, Galeano Pablo, Campanelli Lorenzo, Novack Gisela Vanina, Martinez Luis Eduardo, Medel Nancy, Lisso Julieta, Sevillano Zulma, Irureta Nicolás, Castaño Eduardo Miguel, Montrreal Laura, Thoenes Michaela, Hanses Claudia, Heilmann-Heimbach Stefanie, Kairiyama Claudia, Mintz Inés, Villella Ivana, Rueda Fabiana, Romero Amanda, Wukitsevits Nancy, Quiroga Ivana, Gona Cristian, Lambert Jean-Charles, Solis Patricia, Politis Daniel Gustavo, Mangone Carlos Alberto, Gonzalez-Billault Christian, Boada Mercè, Tàrraga Lluís, Slachevsky Andrea, Albala Cecilia, Fuentes Patricio, Kochen Silvia, Brusco Luis Ignacio, Ruiz Agustín, Morelli Laura, Ramírez Alfredo
Abstract excerpt
INTRODUCTION: Genome-wide association studies (GWAS) are fundamental for identifying loci associated with diseases. However, they require replication in other ethnicities. METHODS: We performed GWAS on sporadic Alzheimer's disease (AD) including 539 patients and 854 controls from Argentina and Chile. We combined our results with those from the European Alzheimer and Dementia Biobank (EADB) in a meta-analysis and...
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