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Article

Role of RyR2 phosphorylation at S2814 during heart failure progression.

Circulation research - 25 May 2012

Respress Jonathan L, van Oort Ralph J, Li Na, Rolim Natale, Dixit Sayali S, deAlmeida Angela, Voigt Niels, Lawrence William S, Skapura Darlene G, Skårdal Kristine, Wisløff Ulrik, Wieland Thomas, Ai Xun, Pogwizd Steven M, Dobrev Dobromir, Wehrens Xander H T

Abstract excerpt

RATIONALE: Increased activity of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is thought to promote heart failure (HF) progression. However, the importance of CaMKII phosphorylation of ryanodine receptors (RyR2) in HF development and associated diastolic sarcoplasmic reticulum Ca(2+) leak is unclear. OBJECTIVE: Determine the role of CaMKII phosphorylation of RyR2 in patients and mice with nonischemic...

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Identifiers

PMID: 22511749
DOI: 10.1161/CIRCRESAHA.112.268094
PMCID: PMC3371642

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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