Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cellular mechanisms of oligoclonal vascular smooth muscle cell expansion in cardiovascular disease.

Cardiovascular research - 22 May 2023

Worssam Matt D, Lambert Jordi, Oc Sebnem, Taylor James C K, Taylor Annabel L, Dobnikar Lina, Chappell Joel, Harman Jennifer L, Figg Nichola L, Finigan Alison, Foote Kirsty, Uryga Anna K, Bennett Martin R, Spivakov Mikhail, Jørgensen Helle F

Abstract excerpt

AIMS: Quiescent, differentiated adult vascular smooth muscle cells (VSMCs) can be induced to proliferate and switch phenotype. Such plasticity underlies blood vessel homeostasis and contributes to vascular disease development. Oligoclonal VSMC contribution is a hallmark of end-stage vascular disease. Here, we aim to understand cellular mechanisms underpinning generation of this VSMC oligoclonality. METHODS AND...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atherosclerosis
Share to Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Cells, Cultured

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Phenotype

Share to Spinocerebellar Ataxias

Source

Open in PubMed Open full text

Identifiers

PMID: 35994249
DOI: 10.1093/cvr/cvac138
PMCID: PMC10202649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cellular mechanisms of oligoclonal vascular smooth muscle cell expansion in cardiovascular disease.PMID 35994249Read ↗

Primed smooth muscle cells acting as first responder cells in diseaseSemantic proximity Read ↗

Mechanisms of vascular smooth muscle cell investment and phenotypic diversification in vascular diseases.Semantic proximity Read ↗

Heterogeneity in vascular smooth muscle cell gene expression and its association with clonal proliferation in models of vascular diseaseSemantic proximity Read ↗

Vascular smooth muscle cell heterogeneity and plasticity in models of cardiovascular diseaseSemantic proximity Read ↗

A genome-wide, single-cell analysis of vascular smooth muscle cell plasticitySemantic proximity Read ↗

A rare pre-existing progenitor-like Primed SMC compartment is the dominant inferred source of SMC-derived cellularity in vascular injury and atherosclerosisSemantic proximity Read ↗

Clonal Expansion in Cardiovascular PathologySemantic proximity Read ↗

Non-coding RNAs: key regulators of smooth muscle cell fate in vascular disease.Semantic proximity Read ↗

Vascular smooth muscle cells in atherosclerosis: time for a re-assessment.Semantic proximity Read ↗

Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human.Semantic proximity Read ↗

Smooth Muscle Heterogeneity and Plasticity in Health and Aortic Aneurysmal Disease.Semantic proximity Read ↗

Role of Diverse Smooth Muscle Cell Phenotypic Transitions in Atherosclerosis Development and Late-Stage Pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.