Article

RAG-mediated structural variation and its impact on relapse risk in acute lymphoblastic leukemia

2026-05-22

Abstract excerpt

Relapse during treatment of B-cell acute lymphoblastic leukemia (B-ALL) is a harbinger of poor outcomes. Identifying biomarkers for subsequent relapse risk which are detectable at B-ALL diagnosis remains a priority. Off-target recombination-activating gene (RAG)-mediated structural variants (SVs) generate genomic instability that drives leukemogenesis and may underlie treatment resistance. Leveraging sequencing da...

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Literature Corpus work: 37a9ad98-df45-5db7-84fa-c9c7650b671f
DOI: 10.64898/2026.05.21.26353542

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