Association of GATA3 Polymorphisms With Minimal Residual Disease and Relapse Risk in Childhood Acute Lymphoblastic Leukemia.

doi:10.1093/jnci/djaa138

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Article

Association of GATA3 Polymorphisms With Minimal Residual Disease and Relapse Risk in Childhood Acute Lymphoblastic Leukemia.

Journal of the National Cancer Institute - 6 Apr 2021

Zhang Hui, Liu Anthony Pak-Yin, Devidas Meenakshi, Lee Shawn Hr, Cao Xueyuan, Pei Deqing, Borowitz Michael, Wood Brent, Gastier-Foster Julie M, Dai Yunfeng, Raetz Elizabeth, Larsen Eric, Winick Naomi, Bowman W Paul, Karol Seth, Yang Wenjian, Martin Paul L, Carroll William L, Pui Ching-Hon, Mullighan Charles G, Evans William E, Cheng Cheng, Hunger Stephen P, Relling Mary V, Loh Mignon L, Yang Jun J

Abstract excerpt

BACKGROUND: Minimal residual disease (MRD) after induction therapy is one of the strongest prognostic factors in childhood acute lymphoblastic leukemia (ALL), and MRD-directed treatment intensification improves survival. Little is known about the effects of inherited genetic variants on interpatient variability in MRD. METHODS: A genome-wide association study was performed on 2597 children on the Children's...

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Identifiers

PMID: 32894760
DOI: 10.1093/jnci/djaa138
PMCID: PMC8680540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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