Article
Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia.
Blood - 15 Nov 2012
Yang Jun J, Cheng Cheng, Devidas Meenakshi, Cao Xueyuan, Campana Dario, Yang Wenjian, Fan Yiping, Neale Geoff, Cox Nancy, Scheet Paul, Borowitz Michael J, Winick Naomi J, Martin Paul L, Bowman W Paul, Camitta Bruce, Reaman Gregory H, Carroll William L, Willman Cheryl L, Hunger Stephen P, Evans William E, Pui Ching-Hon, Loh Mignon, Relling Mary V
Abstract excerpt
With the use of risk-directed therapy for childhood acute lymphoblastic leukemia (ALL), outcome has improved dramatically in the past 40 years. However, a substantial portion of patients, many of whom have no known risk factors, experience relapse. Taking a genome-wide approach, in the present study, we evaluated the relationships between genotypes at 444 044 single nucleotide polymorphisms (SNPs) with the risk...
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