Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia.

doi:10.1182/blood-2016-03-704973

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Article

Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia.

Blood - 18 Aug 2016

Irving Julie A E, Enshaei Amir, Parker Catriona A, Sutton Rosemary, Kuiper Roland P, Erhorn Amy, Minto Lynne, Venn Nicola C, Law Tamara, Yu Jiangyan, Schwab Claire, Davies Rosanna, Matheson Elizabeth, Davies Alysia, Sonneveld Edwin, den Boer Monique L, Love Sharon B, Harrison Christine J, Hoogerbrugge Peter M, Revesz Tamas, Saha Vaskar, Moorman Anthony V

Abstract excerpt

Somatic genetic abnormalities are initiators and drivers of disease and have proven clinical utility at initial diagnosis. However, the genetic landscape and its clinical utility at relapse are less well understood and have not been studied comprehensively. We analyzed cytogenetic data from 427 children with relapsed B-cell precursor ALL treated on the international trial, ALLR3. Also we screened 238 patients...

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Identifiers

PMID: 27229005
DOI: 10.1182/blood-2016-03-704973
PMCID: PMC5026463

Genes

BTG1
NRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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