Article
MicroRNA-30a-5p silencing polarizes macrophages toward M2 phenotype to alleviate cardiac injury following viral myocarditis by targeting SOCS1.
American journal of physiology. Heart and circulatory physiology - 1 Apr 2021
Zhang Yan, Cai Shengbao, Ding Xiaoxue, Lu Can, Wu Ruodan, Wu Haiyan, Shang Yiyi, Pang Mingjie
Abstract excerpt
Viral myocarditis (VMC) is a life-threatening disease characterized by severe cardiac inflammation generally caused by coxsackievirus B3 (CVB3) infection. Several microRNAs (miRNAs or miRs) are known to play crucial roles in the pathogenesis of VMC. The study aimed to decipher the role of miR-30a-5p in the underlying mechanisms of VMC pathogenesis. We first quantified miR-30a-5p expression in a CVB3-induced mouse...
Topics
- Animals
- Antagomirs
- Cells, Cultured
- Coxsackievirus Infections
- Cytokines
- Disease Models, Animal
- Enterovirus B, Human
- Gene Silencing
- Genetic Therapy
- Inflammation Mediators