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A Mouse Upper Respiratory Tract Coronavirus Infection Model with OC43 Defines Toll-Like Receptor 2/6 Mediated Innate Immune Protection

2022-05-19

Abstract excerpt

Background: Despite multiple β-coronavirus (β-CoV) outbreaks, there is limited understanding of the protective immune response at the site of infection – the upper respiratory tract (URT). This is due to limited in vivo models of β-CoV respiratory infection.<br><br>Methods: We administered URT human β-CoV OC43 infection to BALB/c mice and assessed topical pegylated TLR2/6 agonist (INNA-006) treatment. We also inve...

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Literature Corpus work
7a84843c-6b18-581e-99b2-412e53ba1c9d
DOI
10.2139/ssrn.4113979
Open publication

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A Mouse Upper Respiratory Tract Coronavirus Infection Model with OC43 Defines Toll-Like Receptor 2/6 Mediated Innate Immune ProtectionDOI 10.2139/ssrn.4113979
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