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Brain-specific <i>Gata4</i> downregulation in <i>Greywick</i> female mice models the metabolic subtype of polycystic ovary syndrome

2024-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Polycystic ovary syndrome (PCOS) is a heterogenous disorder characterized by reproductive and metabolic abnormalities. PCOS etiology remains poorly understood, although the hypothalamus is suspected to play a central role in many cases. Human genetic studies have also shown an association with the transcription factor-coding gene GATA4 , but without providing a functional link. Here, we show th...

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Literature Corpus work
37773d3a-2884-5af9-94a2-c4726447fa6d
DOI
10.1101/2024.05.13.593880
Open publication

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Brain-specific <i>Gata4</i> downregulation in <i>Greywick</i> female mice models the metabolic subtype of polycystic ovary syndromeDOI 10.1101/2024.05.13.593880
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