Article

Reducing methylation of histone 3.3 lysine 4 in the medial ganglionic eminence and hypothalamus recapitulates neurodevelopmental disorder phenotypes

2025-05-02

Abstract excerpt

<h4>ABSTRACT</h4> Methylation of lysine 4 on histone H3 (H3K4) is enriched on active promoters and enhancers and correlates with gene activation. Disruption of H3K4 methylation is associated with numerous neurodevelopmental diseases (NDDs) that display intellectual disability and abnormal body growth. Here, we perturb H3K4 methylation in the medial ganglionic eminence (MGE) and the hypothalamus, two brain regions...

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Literature Corpus work: fe100311-b76f-5b3f-81a2-d3df19c10d82
DOI: 10.1101/2025.05.02.651761

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