Article
The GPR54 gene as a regulator of puberty.
The New England journal of medicine - 23 Oct 2003
Seminara Stephanie B, Messager Sophie, Chatzidaki Emmanouella E, Thresher Rosemary R, Acierno James S, Shagoury Jenna K, Bo-Abbas Yousef, Kuohung Wendy, Schwinof Kristine M, Hendrick Alan G, Zahn Dirk, Dixon John, Kaiser Ursula B, Slaugenhaupt Susan A, Gusella James F, O'Rahilly Stephen, Carlton Mark B L, Crowley William F, Aparicio Samuel A J R, Colledge William H
Abstract excerpt
BACKGROUND: Puberty, a complex biologic process involving sexual development, accelerated linear growth, and adrenal maturation, is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus. We conducted studies in humans and mice to identify the genetic factors that determine the onset of puberty. METHODS: We used complementary genetic approaches in humans and in mice. A...
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