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High-Fat Diet Induces Epigenetic and Metabolic Changes in Kisspeptin Neurons in Association with Obesity and Male Secondary Hypogonadism

2025-12-02

Abstract excerpt

<h4>Background</h4> Obesity and type 2 diabetes mellitus (T2D) are major risk factors for male hypogonadism, a disorder with multi-system impacts on health. However, the mechanisms underlying obesity-associated male secondary hypogonadism remain poorly understood. Here, we aimed to dissect dysfunction of the hypothalamic–pituitary–testicular (HPT) axis and elucidate underlying epigenetic mechanisms, using a high-...

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Literature Corpus work
074159f7-6ec3-5cf7-9340-871462888620
DOI
10.64898/2025.11.30.691258
Open publication

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High-Fat Diet Induces Epigenetic and Metabolic Changes in Kisspeptin Neurons in Association with Obesity and Male Secondary HypogonadismDOI 10.64898/2025.11.30.691258
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