Article
The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent.
BMC genomics - 28 Apr 2011
Prentice Leah M, d'Anglemont de Tassigny Xavier, McKinney Steven, Ruiz de Algara Teresa, Yap Damian, Turashvili Gulisa, Poon Steven, Sutcliffe Margaret, Allard Pat, Burleigh Angela, Fee John, Huntsman David G, Colledge William H, Aparicio Samuel A J
Abstract excerpt
BACKGROUND: Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin do not progress through puberty, caused by a failure to release GnRH. The transcriptional networks regulated by these proteins in the hypothalamus have yet to be explored by genome-wide methods. RESULTS: We show here, using 1 million exon mouse arrays (Exon 1.0 Affymetrix) and quantitative polymerase chain reaction (QPCR)...
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