Article

Spatial genomics of the cardiac sarcomere

2025-10-07

Abstract excerpt

Structure-function mapping of proteins has improved our understanding of disease mechanisms and protein domains while human population genetics has provided a window into variational tolerance that can be modeled at a structural level. Here, to reveal novel insight into the cardiac sarcomere, the motor unit of the heart, we develop a novel analytical framework to integrate data from over 17,000 patients with hyper...

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Literature Corpus work: 37742edf-ca82-5d26-8791-8b50891f2312
DOI: 10.1101/2025.10.07.680947

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