Article

Variants identify sarcomere inter-protein contacts distinguishing inheritable cardiac muscle diseases

2022-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Human ventriculum myosin (βmys) powers contraction sometimes while complexed with myosin binding protein C (MYBPC3) on the myosin thick filament. The latter regulates βmys activity through inter-protein contacts. Single nucleotide variants (SNVs) change protein sequence in βmys or MYBPC3. They cause inheritable heart disease. When a SNV modified domain locates to an inter-protein contact it affe...

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Literature Corpus work: 05860a1f-8b26-5cff-927c-49428670439d
DOI: 10.1101/2022.03.23.485392

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