Article

Multi-dimensional structure function relationships in human β-cardiac myosin from population scale genetic variation

2016-02-09

Abstract excerpt

Myosin motors are the fundamental force-generating element of muscle contraction. Variation in the human β-cardiac myosin gene ( MYH7 ) can lead to hypertrophic cardiomyopathy (HCM), a heritable disease characterized by cardiac hypertrophy, heart failure, and sudden cardiac death. How specific myosin variants alter motor function or clinical expression of disease remains incompletely understood. Here, we combine...

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Literature Corpus work: 4e8dbb5a-91f9-544f-84e7-e504f96fe06e
DOI: 10.1101/039321

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