Article

Comprehensive Analysis of Constraint on the Spatial Distribution of Missense Variants in Human Protein Structures

2017-02-18

Abstract excerpt

The spatial distribution of genetic variation within proteins is shaped by evolutionary constraint and thus can provide insights into the functional importance of protein regions and the potential pathogenicity of protein alterations. Here, we comprehensively evaluate the 3D spatial patterns of constraint on human germline and somatic variation in 4,568 solved protein structures. Different classes of coding varian...

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Literature Corpus work: cdde9b86-efae-54e4-a952-8f2f225423d5
DOI: 10.1101/109652

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