Article

Natural variants with 2D correlation genetics identify domains coordinating sarcomere proteins during contraction

2021-03-15

Abstract excerpt

Muscle proteins assemble in a sarcomere then by coordinated action produce contraction force to shorten muscle. In the human heart ventriculum, cardiac myosin motor (βmys) repetitively converts ATP free energy into work. Cardiac myosin binding protein C (MYBPC3) in complex with βmys regulates contraction power generation. Their bimolecular complex βmys/MYBPC3 models the contractile system and is used here to study...

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Literature Corpus work: 93286be2-117d-5b47-b0ce-3bfe5872f34e
DOI: 10.1101/2021.03.14.435341

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