Article
Muscle LIM Protein Force-Sensing Mediates Sarcomeric Biomechanical Signaling in Human Familial Hypertrophic Cardiomyopathy.
Circulation - 19 Apr 2022
Riaz Muhammad, Park Jinkyu, Sewanan Lorenzo R, Ren Yongming, Schwan Jonas, Das Subhash K, Pomianowski Pawel T, Huang Yan, Ellis Matthew W, Luo Jiesi, Liu Juli, Song Loujin, Chen I-Ping, Qiu Caihong, Yazawa Masayuki, Tellides George, Hwa John, Young Lawrence H, Yang Lei, Marboe Charles C, Jacoby Daniel L, Campbell Stuart G, Qyang Yibing
Abstract excerpt
BACKGROUND: Familial hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease and is typically caused by mutations in genes encoding sarcomeric proteins that regulate cardiac contractility. HCM manifestations include left ventricular hypertrophy and heart failure, arrythmias, and sudden cardiac death. How dysregulated sarcomeric force production is sensed and leads to pathological remodeling...
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