Article

Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior

2019-06-27

Abstract excerpt

The ventral tegmental area (VTA), an important source of dopamine, regulates goal- and reward-directed and social behaviors, wakefulness and sleep. Hyperactivation of dopamine neurons generates behavioral pathologies. But any roles of non-dopamine VTA neurons in psychiatric illness have been little explored. Lesioning or chemogenetically inhibiting VTA GABAergic (VTA Vgat ) neurons generated persistent wakefulnes...

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Literature Corpus work: 3764f427-37f8-5fe5-aeaf-5b4d16056052
DOI: 10.1101/684142

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