Article

Etrinabdione (VCE-004.8), a B55α activator, promotes angiogenesis and arteriogenesis in critical limb ischemia

2024-04-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Vasculogenic therapies explored for the treatment of peripheral artery disease (PAD) have encountered minimal success in clinical trials. Addressing this, B55α, an isoform of protein phosphatase 2A (PP2A), emerges as pivotal in vessel remodeling through activation of hypoxia-inducible factor 1α (HIF-1α). This study delves into the pharmacological profile of VCE-004.8 (Etrina...

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Literature Corpus work: 375ff100-64e4-52a8-b432-0bec8cd15a96
DOI: 10.1101/2024.04.26.591240

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