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Article

Endothelial Nitric Oxide Synthase-Independent Pleiotropic Effects of Pitavastatin Against Atherogenesis and Limb Ischemia in Mice.

Journal of atherosclerosis and thrombosis - 1 Jan 2018

Mitsuhashi Takeshi, Uemoto Ryoko, Ishikawa Kazue, Yoshida Sumiko, Ikeda Yasumasa, Yagi Shusuke, Matsumoto Toshio, Akaike Masashi, Aihara Ken-Ichi

Abstract excerpt

AIM: Statins have a protective impact against cardiovascular diseases through not only lipid-lowering effects but also pleiotropic effects, including activation of the endothelial nitric oxide synthase (eNOS) system. We aimed to clarify the protective effects of a statin against atherogenesis and ischemia in eNOS－/－ mice. METHODS: Study 1. eNOS－/－ Apolipoprotein E (ApoE)－/－ mice were treated with a vehicle or...

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Identifiers

PMID: 28592707
DOI: 10.5551/jat.37747
PMCID: PMC5770225

Genes

BAX
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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