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Article

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components.

Antimicrobial agents and chemotherapy - 14 Dec 2015

Raj Shriya, Krishnan Karthik, Askew David S, Helynck Olivier, Suzanne Peggy, Lesnard Aurélien, Rault Sylvain, Zeidler Ute, d'Enfert Christophe, Latgé Jean-Paul, Munier-Lehmann Hélène, Saveanu Cosmin

Abstract excerpt

In a search for new antifungal compounds, we screened a library of 4,454 chemicals for toxicity against the human fungal pathogen Aspergillus fumigatus. We identified sr7575, a molecule that inhibits growth of the evolutionary distant fungi A. fumigatus, Cryptococcus neoformans, Candida albicans, and Saccharomyces cerevisiae but lacks acute toxicity for mammalian cells. To gain insight into the mode of...

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Source

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Identifiers

PMID: 26666917
DOI: 10.1128/AAC.02239-15
PMCID: PMC4775935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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