Article

Stress- and metabolic responses of <i>Candida albicans</i> require Tor1 kinase N-terminal HEAT repeats

2021-11-05

Abstract excerpt

Whether to commit limited cellular resources toward growth and proliferation, or toward survival and stress responses, is an essential determination made by Target of Rapamycin Complex 1 (TORC1) for a eukaryotic cell in response to favorable or adverse conditions. Loss of TORC1 function is lethal. The TORC1 inhibitor rapamycin that targets the highly conserved Tor kinase domain kills fungal pathogens like Candida...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4597cc5c-06dc-5442-8c0e-93fb80e3f508
DOI: 10.1101/2021.11.05.467412

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stress- and metabolic responses of <i>Candida albicans</i> require Tor1 kinase N-terminal HEAT repeatsDOI 10.1101/2021.11.05.467412Read

Phosphate is the third nutrient monitored by TOR in <i>Candida albicans</i> and provides a target for fungal-specific indirect TOR inhibitionSemantic proximity Read

The Candida albicans TOR-Activating GTPases Gtr1 and Rhb1 Coregulate Starvation Responses and Biofilm FormationSemantic proximity Read

Hyperactive TORC1 sensitizes yeast cells to endoplasmic reticulum stress by compromising cell wall integritySemantic proximity Read

Target of Rapamycin (TOR) Regulates Growth in Response to Nutritional SignalsSemantic proximity Read

Glucose Promotes Stress Resistance in the Fungal Pathogen<i>Candida albicans</i>Semantic proximity Read

The protein kinase Tor1 regulates adhesin gene expression in Candida albicans.Semantic proximity Read

Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition.Semantic proximity Read

The TOR Pathway Plays Pleiotropic Roles in Growth and Stress Responses of the Fungal Pathogen Cryptococcus neoformansSemantic proximity Read

Integration of the tricarboxylic acid (TCA) cycle with cAMP signaling and Sfl2 pathways in the regulation of CO2 sensing and hyphal development in Candida albicansSemantic proximity Read

Transcriptional Profiling of Patient Isolates Identifies a Novel TOR Regulatory Pathway in Cryptococcal VirulenceSemantic proximity Read

Crosstalk between the Ino80 complex and TOR signaling drives fungal adaptation to hypoxia through chromatin remodelingSemantic proximity Read

<i>Candida albicans</i> exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compoundsSemantic proximity Read