Article

Distinct Ire1-driven transcriptional responses control morphogenesis in <i>Candida albicans</i>

2025-11-14

Abstract excerpt

<h4>ABSTRACT</h4> The pathogenic yeast Candida albicans relies on morphogenesis—the transition from spherical yeast to filamentous hyphal forms—for infection. While morphogenesis requires Ire1, a transmembrane protein that canonically initiates the Unfolded Protein Response (UPR) through HAC1 mRNA splicing, the specific mechanisms linking Ire1 to filamentation remain unclear. Using transcriptome analysis, we fo...

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Literature Corpus work: c7a7a64e-936f-5eb2-8596-f751bfec967a
DOI: 10.1101/2025.11.13.688365

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