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Identification and Validation of Tryptophan Metabolism–Related Genes in Diabetic Kidney Disease and Construction of a Clinical Prediction Model

1 Jan 2025

Abstract excerpt

Background: Diabetic kidney disease (DKD) is a common microvascular complication of diabetes mellitus (DM). Amino acid (AA) homeostasis has an important impact on renal hemodynamics and glomerular hyperfiltration in patients with DKD, and the metabolite level of tryptophan (TRP), an AA, has been associated with various diseases. Methods: In this study, DKD tubule‐ and glomerulus‐related microarray datasets were...

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PMID: 40376698
DOI: 10.1155/jdr/2736801

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