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IDO1 promotes CSFV replication by mediating tryptophan metabolism to inhibit NF-κB signaling

30 May 2024

Abstract excerpt

Tryptophan metabolism plays a crucial role in facilitating various cellular processes essential for maintaining normal cellular function. Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the conversion of tryptophan (Trp) into kynurenine (Kyn), thereby initiating the degradation of Trp. The resulting Kyn metabolites have been implicated in the modulation of immune responses. Currently, the role of IDO1-mediated...

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PMID: 38814067
DOI: 10.1128/jvi.00458-24

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